Clean generation of a fluoroaryl grignard reagent

US6248265A · kind A · utility

Assignee

• ALBEMARLE CORPORATION · US

Inventors

• John Y. Lee · Baton Rouge, US
• David W. Owens · Baton Rouge, US
• Charles R. Everly · Baton Rouge, US
• Ronny W. Lin · Sugar Land, US
• John M. Power · Garland, US
• Steven P. Diefenbach · Baton Rouge, US
• Niomi L. Krzystowczyk · Baton Rouge, US

Key dates

• Filing date: Jun 16, 2000
• Grant date: Jun 19, 2001
• Expiry date: Jun 16, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F3/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Fluoroaryl Grignard reagents are produced from a hydrocarbyl Grignard reagent and fluoroaromatic compounds via separate additions of different fluoroaromatic compounds, such that the conversion of hydrocarbyl Grignard reagent to the desired fluoroaryl Grignard reagent is essentially complete, and thus the reaction product is free or essentially free of agents that may negatively affect subsequent reactions. The fluoroaryl Grignard reagents may be further reacted with boron trihalides in order to obtain tris(fluoroaryl)boranes or tetrakis(fluoroaryl)borates.