Compositions for preserving haptenized tumor cells for use in vaccines
US6248585A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Nov 16, 1999 |
| Grant date | Jun 19, 2001 |
| Priority date | — |
| Expiry date | Nov 16, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/6081
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition comprising an isotonic, buffered aqueous medium containing an optimized concentration of human serum albumin has been found to stabilize irradiated, haptenized tumor cells stored for some period of time after haptenization. In specific embodiments, the viability of the haptenized tumor cells stored in a composition of the invention ranged from about 60% to about 100% greater than the cell viability of cells stored in a prior art solution. In a specific embodiment, 1% human serum albumin in Hank's Buffered Salt Solution was found to stabilize haptenized melanoma cells. Methods of storing haptenized tumor cells and vaccine preparations are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.