Antisense oligonucleotide compositions targeted to angiotensin converting enzyme MRNA and methods of use
US6248724A · kind A · utility
24Cited by
4References
59Claims
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Key dates
| Filing date | Sep 25, 1998 |
| Grant date | Jun 19, 2001 |
| Priority date | — |
| Expiry date | Sep 25, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/916
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Antisense oligonucleotides specific for mammalian ACE mRNA have been identified. Administration of these oligonucleotides to animals resulted in a decrease in blood pressure, but no significant change in heart rate. Methods for discovering other oligonucleotides with the same activity are taught, as are uses of the antisense molecules for treatment of human and animal diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.