Azabicyclooctane compositions and methods for enhancing chemotherapy
US6248752A · kind A · utility
Inventor
Key dates
| Filing date | Feb 25, 1999 |
| Grant date | Jun 19, 2001 |
| Priority date | — |
| Expiry date | Feb 25, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K45/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compositions and methods for enhancing the efficacy of therapeutic or prophylactic drugs. These compositions and methods are particularly useful to inhibit the abilities of drug transport proteins to efflux therapeutic agents from cells. Utilities of said compositions and methods include sensitizing drug resistant cells to anti-cancer agents, preventing the development of such drug resistance, enhancing the availability of therapeutic agents to the brain, testes, eyes and leukocytes, enhancing the oral bioavailability of therapeutic agents, sensitizing drug resistant infectious organisms to anti-infection agents, and preventing the development of such drug resistance.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.