Imidazole derivatives as histamine receptor H3 (ANT) agonists

US6248765A · kind A · utility

Assignees

• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR
• BIOPROJET · FR

Inventors

• Jean-Charles Schwartz · Paris, FR
• Jean-Michel Arrang · Gif-sur-Yvette, FR
• Monique Garbarg · Paris, FR
• Agnes Quemener · Nantes, FR
• Jeanne-Marie Lecomte · Paris, FR
• Xavier Ligneau · Brive-la-Gaillarde, FR
• Walter Schunack · Berlin, DE
• Holger Stark · Bad Homburg vor der Höhe, DE
• Katja Purand · Berlin, DE
• Annette Huls · Berlin, DE
• Reidemeister Sybille · Berlin, DE
• Athmani Salah · Glasgow, GB
• Charon Ganellin · Thame, GB
• Nadia Pelloux-Leon · Meylan, FR
• Wasyl Tertiux · Hertford, GB
• Michael KRAUSE · Berlin, DE
• Sadek Bassem · Berlin, DE

Key dates

• Filing date: Jan 9, 1997
• Grant date: Jun 19, 2001
• Expiry date: Jan 9, 2017

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/726
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Novel imidazole derivatives as histamine receptor H.sub.3 antagonists and/or agonists, preparation thereof and therapeutical uses thereof. Chemical compounds for use as histamine receptor H.sub.3 agonists, partial agonists or antagonists, having general formula (Ia) or (Ib), the use thereof for making drugs, and methods for revealing the agonist, partial agonist or antagonist activity of such compounds in vivo, are disclosed. ##STR1##