Diagnostic and therapeutic alkylenediamine compounds and process
US6251363A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Nov 1, 1999 |
| Grant date | Jun 26, 2001 |
| Priority date | — |
| Expiry date | Nov 1, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D241/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Diamine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The diamine compounds or serotonin are characterized by the formula: ##STR1## l, m and n can be the same or different and are an integer of 1 to 6; X, Y and Z can be the same or different and are hydrogen, halo, haloalkyl, (C.sub.1 -C.sub.6) alkyl, aryl, (C.sub.1 -C.sub.6) alkoxy, N-alkyl, (C.sub.2 -C.sub.6) acyloxy, N-alkylene, --SH or --SR, wherein R is from the same group as R.sub.1 and R.sub.2 and can be the same or different than R.sub.1 and R.sub.2, amino, nitro, cyano, hydroxy, --C(.dbd.O) OR.sub.6, --C(.dbd.O) NR.sub.5 R.sub.4, NR.sub.3 R.sub.2, or S(.dbd.O).sub.k R.sub.i wherein .sub.k is 1 or 2, and R.sub.4 to R.sub.6 are independently hydrogen or (C.sub.1 -C.sub.6) alkyl; R.sub.1, and R.sub.2 can be the same or different and are hydrogen, (C.sub.1 -C.sub.6) alkyl, hydroxyalkyl or mercaptoalkyl, --C(.dbd.O) OR.sub.1, cyano, (C.sub.1 -C.sub.6) alkenyl, (C.sub.2 -C.sub.6) alkynyl or 1, 2, 4-oxadiazol-5-yl optionally substituted at he 3-position by W wherein any (C.sub.1 -C.sub.6) alky, (C.sub.1 -C.sub.6) alk…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.