Method and a system for enhanced in vivo clearance of diagnostic and/or therapeutic agents by extracorporeal depletion, and the use of said agents for said purpose

US6251394A · kind A · utility

Assignee

• MITRA MEDICAL TECHNOLOGY AB · SE

Inventors

• Rune Nilsson · Anderstorp, SE
• Lars Lindgren · Helsingborg, SE
• Kristina Norrgren
• Bengt Sandberg · Hjärup, SE
• Hans Olof Sjogren · Lund, SE
• Sven-Erik Strand · Lund, SE

Key dates

• Filing date: Oct 12, 1993
• Grant date: Jun 26, 2001
• Expiry date: Oct 12, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2123/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method and a system is described for reducing non-target levels of specific molecules intended for diagnostic and/or therapeutic applications to vertebrate hosts, wherein said molecules are administered to a vertebrate host and kept therein for a certain time in order to be concentrate to the target by being attached thereto. The molecules which are not attached to the target are removed from the blood circulation system or at least reduced to a lower concentration by passing the blood through an extra-corporeal device.