Sustained release dosage form unit having latex coating and method of making the same

US6251432A · kind A · utility

Assignee

• Abbott Laboratories · US

Inventors

• Terrence B. Mazer · Reynoldsburg, US
• Joseph E. Walton · Westerville, US
• Barbara S. Arnholt · Worthington, US
• Monty L. Evans · Johnstown, US
• Ronita K. Geckle · Columbus, US
• Daniel Hamilton · Plain City, US
• John J. Kropczynski, Jr. · Dublin, US
• Frank A. Murawski · Westerville, US
• Larry G. Tucker · Powell, US
• Sherri A. Walker · Sunbury, US
• Michael V. Walsh · Westerville, US
• Rhonda Cole Walsh · Westerville, US

Key dates

• Filing date: Jul 1, 1999
• Grant date: Jun 26, 2001
• Expiry date: Jul 1, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/209
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Dosage form unit is provided to deliver one or more beneficial agents into a fluid, such as liquid enteral nutritional product. The dosage form unit includes a core containing at least one beneficial agent, preferably a marker dye, which is dispersible in the fluid. The core also contains a compatible binding agent to bind the beneficial agent together. Additional components of the core may include a plasticizer, a standard flow agent, a lubricant, additional tableting aids and at least one hydrophilic agent. A latex coating encases the core. The latex coating includes a mixture containing a substantially hydrophobic base material, preferably formed from an emulsion of cellulose acetate microspheres, which is capable of defining a matrix-type membrane, and at least one hydrophilic component being dispersible in the fluid. A dispersible beneficial agent is preferred as one of the hydrophilic components of the latex coating to allow immediate release of the beneficial agent therefrom. A method of making the dosage form unit also is provided.