Oxidative stabilization of collagen containing materials
US6251579A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 13, 1998 |
| Grant date | Jun 26, 2001 |
| Priority date | — |
| Expiry date | Feb 13, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08H1/06
- WIPO fieldBasic materials chemistry
- WIPO sectorChemistry
Abstract
This invention relates, in general, to a process for cross-linking and stabilizing proteinaceous material, and in particular, to a process for oxidizing collagenous material, by oxidizing the tissue. The invention also relates to the resulting cross-linked product. The method comprises immersing the material to be cross-linked in a solution comprising compounds designed to generate the radical species singlet oxygen or other oxidizing intermediates without the addition of an external energy source. Immersing collagen containing tissue in a solution comprising an oxidizing agent and sufficient dissolved oxygen, under controlled conditions of pH and temperature, provides a cross-linked and stabilized collagen containing tissue that resists chemical and enzymatic degradation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.