Cancer diagnostic method based upon DNA methylation differences
US6251594A · kind A · utility
99Cited by
1References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 9, 1998 |
| Grant date | Jun 26, 2001 |
| Priority date | — |
| Expiry date | Jun 9, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6858
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
There is disclosed a cancer diagnostic method based upon DNA methylation differences at specific CpG sites. Specifically, the inventive method provides for a bisulfite treatment of DNA, followed by methylation-sensitive single nucleotide primer extension (Ms-SNuPE), for determination of strand-specific methylation status at cytosine residues.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.