Method for determining status of a cancerous condition by determining antibodies to NY-ESO-1 in a patient sample

US6251603A · kind A · utility

Assignee

• LUDWIG INSTITUTE FOR CANCER RESEARCH LTD · GB

Inventors

• Elke Jager · Frankfurt am Main, DE
• Elisabeth Stockert · New York, US
• Lloyd J. Old · New York, US
• Alexander Knuth · Frankfurt am Main, DE

Key dates

• Filing date: Jul 23, 1999
• Grant date: Jun 26, 2001
• Expiry date: Jul 23, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K39/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to methods for determining tumor status by determining antibodies specific to NY-ESO-1 in patient samples. One can determine whether a cancerous condition is progressing, regressing, or remaining stable by determining antibodies against NY-ESO-1 in a patient sample, and comparing the value obtained to a prior value. When the tumor in question expresses NY-ESO-1, a change in this value is indicative of a change in status of the cancerous condition.