Process for preparing peptides and N-carbamoyl-protected peptides

US6251625A · kind A · utility

Assignee

• Degussa AG · DE

Inventors

• Andreas Bommarius · Frankfurt, DE
• Karlheinz Drauz · Alzenau, DE
• Uwe Eichhorn · Großerkmannsdorf, DE
• Hans-Dieter Jakubke · Leipzig, DE
• Matthias Kottenhahn · Alzenau, DE

Key dates

• Filing date: Apr 3, 1998
• Grant date: Jun 26, 2001
• Expiry date: Apr 3, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention concerns a process for the enzymatic preparation of protected di- and oligopeptides and the separation of the protective groups used. The process according to the invention enables peptides to be synthesized simply and economically and the protective group to be separated carefully. The process comprises three reaction steps: 1. Preparation of N-carbamoyl amino acid or N-carbamoyl amino acid derivatives; 2. Formation of the peptide bond between the carbamoyl-protected electrophile and nucelophile; and 3. Separation of the carbamoyl-protective group.