Peptides and compounds that bind to a receptor

US6251864A · kind A · utility

Assignee

• Glaxo Group Limited · GB

Inventors

• William J. Dower · Menlo Park, US
• Ronald W. Barrett · Saratoga, US
• Steven E. Cwirla · Menlo Park, US
• Christian M. Gates · Santa Cruz, US
• Peter J. Schatz · Cupertino, US
• Palaniappan Balasubramanian · Cupertino, US
• Christopher R. Wagstrom · Los Altos, US
• Richard Wayne Hendren · Cary, US
• Randolph B. DePrince · Terre Haute, US
• Surekha Podduturi · San Jose, US
• Qun Yin · Palo Alto, US

Key dates

• Filing date: Mar 1, 2000
• Grant date: Jun 26, 2001
• Expiry date: Mar 1, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/524
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.