Inhibition of UV-induced immune suppression and interleukin-10 production by cytoprotective tamarind oligosaccharides
US6251878A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jul 7, 1999 |
| Grant date | Jun 26, 2001 |
| Priority date | — |
| Expiry date | Jul 7, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/716
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions are disclosed for the prevention and/or treatment of immunological damage to skin exposed to ultraviolet irradiation. The compositions described herein include biologically active tamarind seed xyloglucan oligosaccharides obtained via treatment of tamarind xyloglucan with a fungal .beta.-glucanase. Advantageously, the cytoprotective tamarind seed xyloglucan oligosaccharides are stable at ambient conditions. In one aspect, the composition includes an aqueous solution of tamarind seed xyloglucan oligosaccharides having a concentration of at least 10.sup.-6 .mu.g per mL of the solution. In another aspect, the method includes preventing the suppression of delayed type hypersensitivity. In yet another aspect, the invention includes reducing the amount of interleukin-10 produced by keratinocytes in the skin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.