Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
US6251893A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 18, 1998 |
| Grant date | Jun 26, 2001 |
| Priority date | — |
| Expiry date | Sep 18, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are compounds with affinity for the 5-HT.sub.6 receptor, which have the general formula: ##STR1## PA0 wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently selected from the group consisting of H, halo, OH, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-7 cycloalkyl and others; PA0 R.sup.5 is selected from the group consisting of SO.sub.2 Ar, C(O)Ar, Ar and CH.sub.2 Ar; PA0 R.sup.6 and R.sup.7 are independently selected from the group consisting of H, C.sub.1-6 alkyl, optionally substituted phenyl and optionally substituted benzyl; PA0 ---------- represents a single or double bond; PA0 n is selected from an integer of from 1-3; PA0 X is selected from the group consisting of CR.sup.17 and N; PA0 Z is selected from the group consisting of C, CH and N, provided that when PA0 ---------- is a double bond, Z is C and when ---------- is a single bond, Z is selected from CH and N; PA0 Ar is an optionally substituted aromatic group selected from the group consisting of phenyl, pyridyl, thienyl, furanyl, naphthyl, quinolyl and isoquinolyl; PA0 R.sup.16 is selected from the group consisting of H, C.sub.1-6 alkyl and benzyl. Also des…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.