Piperazine derivatives

US6251908A · kind A · utility

Assignee

• MERCK PATENT GESELLSCHAFT MIT BESHRANK TER HAFTUNG · DE

Inventors

• Henning Bottcher · Darmstadt, DE
• Gerd Bartoszyk · Weiterstadt, DE
• Hartmut Greiner · Darmstadt, DE
• Christoph Seyfried · Seeheim-Jugenheim, DE

Key dates

• Filing date: Apr 3, 2000
• Grant date: Jun 26, 2001
• Expiry date: Apr 3, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Piperazine derivatives of the formula I ##STR1## in which PA1 R.sup.1, m, k and R.sup.2 have the meanings indicated in claim 1, are potent 5-HT.sub.1A agonists and exhibit 5-HT-reuptake-inhibiting actions and are suitable for the treatment and prophylaxis of anxiety states, depression, schizophrenia, obsessions, tardive dyskinesias, learning disorders, age-dependent memory disorders, for positively affecting obsessive-compulsive disorder, and also for the treatment and for the control of the sequelae of cerebral infarcts such as stroke and cerebral ischaemias.