Antithrombotic diamines

US6251921A · kind A · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Jolie Anne Bastian · Indianapolis, US
• Nickolay Y Chirgadze · Carmel, US
• Michael Lyle Denney · Franklin, US
• Matthew Joseph Fisher · Mooresville, US
• Robert J. Foglesong · Durham, US
• Richard Waltz Harper · Indianapolis, US
• Mary G. Johnson · Carrboro, US
• Valentine Joseph Klimkowski · Carmel, US
• Todd J. Kohn · Thousand Oaks, US
• Ho-Shen Lin · Indianapolis, US
• Michael P Lynch · Raleigh, US
• Jefferson Ray McCowan · Indianapolis, US
• Alan David Palkowitz · Carmel, US
• Michael Enrico Richett · Indianapolis, US
• Daniel Jon Sall · Greenwood, US
• Gerald Floyd Smith · Indianapolis, US
• Kumiko Takeuchi · Indianapolis, US
• Jennifer Marie Tinsley · Ypsilanti, US
• Minsheng Zhang · Hackettstown, US

Key dates

• Filing date: May 14, 1999
• Grant date: Jun 26, 2001
• Expiry date: May 14, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.