Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia
US6251936A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 10, 1999 |
| Grant date | Jun 26, 2001 |
| Priority date | — |
| Expiry date | May 10, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/74
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides compounds of Formula I having the structure ##STR1## PA1 E is S, SO, SO.sub.2, O, or NR.sup.1c ; PA1 X is hydrogen, halogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, CN, aryl, aralkyl of 6-12 carbon atoms, hydroxyalkyl of 1-6 carbon atoms, hydroxyaralkyl of 6-12 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, aryloxy; arylalkoxy, nitro, amino, NR.sup.2 R.sup.2a, NR.sup.2 COR.sup.2a, cycloalkylamino of 3-8 carbon atoms, morpholino, alkylsulfanyl of 1-6 carbon atoms, arylsulfanyl, pyridylsulfanyl, 2-N,N-dimethylaminoethylsulfanyl, --OCH.sub.2 CO.sub.2 R.sup.2b or --COR.sup.2c ; PA1 Z.sup.1 and Z.sup.2 are each, independently, hydrogen, halogen, CN, alkyl of 1-6 carbon atoms, aryl, aralkyl of 6-12 carbon atoms, cycloalkyl of 3-8 carbon atoms, nitro, amino, --NR.sup.1 R.sup.1a, --NR.sup.1 COR.sup.1a, cycloalkylamino of 3-8 carbon atoms, morpholino, or OR.sup.8, or Z.sup.1 and Z.sup.2 may be taken together as a diene unit having the formula --CH.dbd.CR.sup.9 --CR.sup.10.dbd.CR.sup.11 --; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hype…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.