Phenylethylamine derivatives
US6251938A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jun 18, 1999 |
| Grant date | Jun 26, 2001 |
| Priority date | — |
| Expiry date | Jun 18, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C271/56
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention is directed to compounds of the following formula: ##STR1## wherein m is from 0-4; X is O or S; Y is halogeno; R.sub.1 is hydrogen or C.sub.1-4 alkyl; R.sub.2 is hydrogen, C.sub.1-4 alkyl or optionally substituted propargyl; and R.sub.3 and R.sub.4 are each independently hydrogen, C.sub.1-8 alkyl, C.sub.6-12 aryl, C.sub.6-12 cycloalkyl or C.sub.6-12 aralkyl, R.sub.5 is hydrogen or C.sub.1-4 alkyl; and pharmaceutically acceptable salts thereof, provided that when X is O, R.sub.2 is optionally substituted propargyl. This invention is also directed to the use of these compounds for treating depression, Attention Deficit Disorder (ADD), Attention Deficit and Hyperactivity Disorder (ADHD), Tourette's Syndrome, Alzheimer's Disease and other dementia's such as senile dementia, dementia of the Parkinson's type, vascular dementia and Lewy body dementia. This invention is further directed to a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.