Certain benzothiazine dioxide endothelin antagonists and processes for their preparation
US6252070A · kind A · utility
2Cited by
2References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 7, 2000 |
| Grant date | Jun 26, 2001 |
| Priority date | — |
| Expiry date | Aug 7, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 ##STR1## The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.