Process for production of donepezil derivative
US6252081A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 27, 2000 |
| Grant date | Jun 26, 2001 |
| Priority date | — |
| Expiry date | Jun 27, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/32
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a novel industrially or economically preferable process for production of a hydrogen halogenide salt of a Donepezil derivative having an excellent pharmacological action as medicament, namely, reaction of 1-indanone derivative with carbonate ester to obtain 2-alkoxycarbonyl-1-indanone derivative, followed by reaction with halogenated (4-pyridyl)methyl or a salt thereof and decarboxylation successively to obtain 2-(4-pyridyl)methyl-1-indanone derivative, then reaction with halogenated benzyl to obtain quaternary ammonium salt, then reduction, and synthetic intermediates thereof. ##STR1## (Wherein R.sup.1 represents a hydrogen atom or lower alkoxy; n represents an integer of 1 to 4; R.sup.2 represents lower alkyl group; and X represents a halogen atom.)
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.