Chip for performing an electrophoretic separation of molecules and method using same
US6254754A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 26, 1999 |
| Grant date | Jul 3, 2001 |
| Priority date | — |
| Expiry date | Jul 26, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N27/44773
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A chip for performing an electrophoretic separation of micromolecular or macromolecular structures in two dimensions comprises a base substrate comprising a main surface. A channel is formed in the main surface of said base substrate in a first direction, wherein a first voltage is applicable across the channel in order to allow a separation of micromolecular structures or macromolecular structures in the first direction on the basis of a first separation mechanism. In addition, a two-dimensional separation matrix is formed in the main surface of the base substrate, wherein the separation matrix comprises a shallow recess and an array of stand-alone posts arranged in the recess. The recess extends perpendicular from the channel in a second direction, wherein a second voltage is applicable across the separation matrix in order to allow a separation of the structures on the basis of a second separation mechanism.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.