cDNA encoding peptidyl-glycine alpha-amidating monooxygenase (PAM)

US6255067A · kind A · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Henry T. Keutmann · Concord, US
• Peter Schofield · San Francisco, US
• Henry Rodriguez · Animas, US
• Betty Eipper · Baltimore, US
• Richard K. Mains · Baltimore, US

Key dates

• Filing date: Sep 15, 1987
• Grant date: Jul 3, 2001
• Expiry date: Sep 15, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y114/17003
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The sequence of bovine PAM is taught as well as new forms of PAM not known before. One new form is membrane bound and provides the basis of methods for alpha-amidating inactive precursors of peptide hormones.