Recombinant poliovirus vector and method of preparing the same
US6255104A · kind A · utility
0Cited by
3References
1Claims
0Family size
Inventor
Key dates
| Filing date | May 12, 1998 |
| Grant date | Jul 3, 2001 |
| Priority date | — |
| Expiry date | May 12, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a recombinant poliovirus vector and method of making the vector. The recombinant poliovirus vector comprises an RNA polymerase promoter operably linked to a poliovirus nucleic acid sequence which has been altered by removal of the CelII-SnaBI fragment and insertion of a heterologous nucleic acid sequence encoding a protein of interest. The heterologous nucleic acid sequence is flanked on both sides by internal ribosomal entry sites which allow for the expression of the encoded protein of interest and subsequent proteins encoded by the altered poliovirus nucleic acid sequence.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.