Gene delivery by secretory gland expression
US6255289A · kind A · utility
4Cited by
16References
8Claims
0Family size
Assignee
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Key dates
| Filing date | Aug 7, 1998 |
| Grant date | Jul 3, 2001 |
| Priority date | — |
| Expiry date | Aug 7, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P5/48
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Secretory gland cells, particularly pancreatic and salivary gland cells, are genetically altered to operatively incorporate a gene which expresses a protein which has a desired therapeutic effect on a mammalian subject. The expressed protein is secreted directly into the gastrointestinal tract and/or blood stream to obtain therapeutic blood levels of the protein thereby treating the patient in need of the protein. The transformed secretory gland cells provide long term therapeutic cures for diseases associated with a deficiency in a particular protein or which are amenable to treatment by overexpression of a protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.