Pyrazine compounds
US6255307A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 25, 1999 |
| Grant date | Jul 3, 2001 |
| Priority date | — |
| Expiry date | Aug 25, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D241/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A compound of formula (I) wherein R.sup.1 is selected from the group consisting of phenyl substituted by one or more halogen atoms, naphthyl and naphthyl substituted by one or more halogen atoms; R.sup.2 is selected from the group consisting of --NH.sub.2 and --NHC(.dbd.O)R.sup.a ; R.sup.3 is selected from the group consisting of --NR.sup.b R.sup.c, --NHC(.dbd.O)R.sup.a and hydrogen, R.sup.4 is selected from the group consisting of hydrogen, -C.sub.1-4 alkyl, -C.sub.1-4 alkyl substituted by one or more halogen atoms, --CN, --CH.sub.2 OH, --CH.sub.2 OR.sup.d and --CH.sub.2 S(O).sub.x R.sup.d ; wherein R.sup.a represents C.sub.1-4 alkyl or C.sub.3-7 cycloalkyl, and R.sup.b and R.sup.c, which may be the same or different, are selected from hydrogen and C.sub.1-4 alkyl, or together with the nitrogen atom to which they are attached, form a 6-membered nitrogen containing heterocycle, which heterocycle can be further susbtituted with one or more C.sub.1-4 alkyl; R.sup.d is selected from C.sub.1-4 alkyl or C.sub.1-4 alkyl substituted by one or more halogen atoms; x is an integer zero, one or two; and pharmaceutically acceptable derivatives thereof; with the proviso that R.sup.1 does not re…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.