Substituted 2-oxo-alkanoic acid-[2-(indol-3-yl)-ethyl] amides

US6255335A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Thomas Himmler · Odenthal, DE
• Franz Pirro · Langenfeld, DE

Key dates

• Filing date: Oct 11, 2000
• Grant date: Jul 3, 2001
• Expiry date: Oct 11, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to novel N-[2-(indol-3-yl)ethyl]-2-oxo-alkanarnides of the general formula (I) ##STR1## in which PA1 R.sup.1 represents optionally branched C.sub.1 -C.sub.8 -alkyl or C.sub.4 -C.sub.8 -cycloalkyl, PA1 R.sup.2 independently of R.sup.3 represents hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -thioalkyl, phenyl or halogen, PA1 R.sup.3 represents hydrogen, C.sub.1 -C.sub.4 -alkyl or halogen and PA1 R.sup.4 represents optionally branched C.sub.1 -C.sub.6 -alkyl, C.sub.4 -C.sub.6 -cycloalkyl, phenyl which is optionally mono- to trisubstituted by C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.3 -alkoxy, C.sub.1 -C.sub.3 -thioalkyl, halogen, nitro or amino or benzyl which is optionally mono- to trisubstituted by C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.3 -alkoxy, C.sub.1 -C.sub.3 -thioalkyl, halogen, nitro or amino, to processes for their preparation and to their use in antibacterial compositions.