Prodrugs activated by targeted catalytic proteins

US6258360A · kind A · utility

Assignee

• IGEN International, Inc. · US

Inventors

• Reid W. von Borstel · Potomac, US
• Jan Casadei · Bethesda, US
• Balreddy Kamireddy · Rockville, US
• John Kenten · Gaithersburg, US
• Mark Martin · Bethesda, US
• Richard J. Massey · Rockville, US
• Andrew Napper · Salem, US
• David M. Simpson · Murfreesboro, US
• Rodger Smith · Jefferson, US
• Richard C. Titmas · Rockville, US
• Richard O. Williams · Potomac, US

Key dates

• Filing date: Oct 18, 1994
• Grant date: Jul 10, 2001
• Expiry date: Oct 18, 2014

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/00
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Prodrugs that are activated by and conjugated to a catalytic antibody conjugated to a moiety that binds to a tumor cell population are provided.