Antibacterial phosphoinositides
US6258375A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 5, 1998 |
| Grant date | Jul 10, 2001 |
| Priority date | — |
| Expiry date | Mar 5, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA23L33/10
- WIPO fieldFood chemistry
- WIPO sectorChemistry
Abstract
It has been discovered that certain phosphoinositides demonstrate antibacterial activity. Particularly, these phosphoinositides have been discovered to prevent the adhesion of H. influenzae onto the nasopharyngeal cells of mammals, and, in particular, humans. Phosphoinositides useful with the present invention have the following formula: ##STR1## wherein R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen and monounsaturated and saturated fatty acids having a carbon chain length of C.sub.6 to C.sub.20 and R.sub.1 and R.sub.2 can be the same or different; and R.sub.3 to R.sub.7 are selected from the group consisting of hydrogen or a phosphate moiety with at least two of R.sub.3 to R.sub.7 being a phosphate moiety; and hydrates and pharmaceutically acceptable salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.