Expression monitoring of downstream genes in the BRCA1 pathway

US6258536A · kind A · utility

Inventors

• Jonathan Daniel Oliner · Garrett Park, US
• Fred Christians · Los Altos Hills, US
• Vivi Truong · Mountain View, US
• Daniel A. Haber · Sharon, US
• James Bean · Arlington, US
• David Miklos · Brookline, US
• Denis Paul Harkin · Magherafelt, GB

Key dates

• Filing date: Dec 1, 1998
• Grant date: Jul 10, 2001
• Expiry date: Dec 1, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/6809
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Analysis of the genes whose expression is affected by BRCA1 has identified a set of genes, each of which is up- or down-regulated by BRCA1. Each of these genes, alone or in groups, can be used to determine the mutational status of a BRCA1 gene, to determine whether a particular allelic variant affects BRCA1 function, to diagnose neoplasia, and to help identify candidate drugs which may be useful as anti-neoplastic agents.