Variants of apolipoprotein A-I

US6258596A · kind A · utility

Assignee

• Aventis Pharmaceuticals Products Inc. · US

Inventors

• Patrick Benoit · Paris, FR
• Eric Bruckert · Paris, FR
• Patrice Denefle · Châteauroux, FR
• Nicolas Duverger · Paris, FR
• Jean-Charles Fruchart · Lomme, FR
• Gerald Luc · Marcq-en-Barœul, FR
• Gerard Turpin · Paris, FR
• Gerd Assmann · Munster, DE
• Harald Funke · Munster, DE

Key dates

• Filing date: Jun 5, 1998
• Grant date: Jul 10, 2001
• Expiry date: Jun 5, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2799/022
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to variants of the human apolipoproteine A-I comprising a cystein in position 151, the corresponding nucleic acids and the vectors containing them. It also relates to pharmaceutical compositions comprising said elements and their utilization, particularly in genic therapy.