Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US6258603A · kind A · utility
55Cited by
1References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 20, 1999 |
| Grant date | Jul 10, 2001 |
| Priority date | — |
| Expiry date | May 20, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6897
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to an improved method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The improvement resides in a select group of non-steroid ligands which show improved activity over known ligands.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.