Carrier for in vivo delivery of a therapeutic agent
US6258774A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 19, 1998 |
| Grant date | Jul 10, 2001 |
| Priority date | — |
| Expiry date | Mar 19, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A carrier for in vivo delivery of a therapeutic agent comprising a thiol group is provided, wherein the therapeutic agent is conjugated to the carrier via a biodegradable disulfide bond. Since extracellular fluids in vivo do not provide the appropriate environment to efficiently reduce a disulfide bond, while cellular cytosol does provide an appropriate environment, the agent will remain substantially coupled to the carrier while circulating through the body until the carrier crosses a cell membrane. As a result, the therapeutic agent is protected from degradation and renal clearance, and the potential for the therapeutic agent to elicit an immune response is limited.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.