Substituted pyrazin-2-yl-sulphonamide (-3-pyridyl) compounds and uses thereof
US6258817A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 15, 2000 |
| Grant date | Jul 10, 2001 |
| Priority date | — |
| Expiry date | Feb 15, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns pharmaceutically useful compounds of the formula I, in which A.sup.1, A.sup.2, A.sup.3, A.sup.4, B.sup.1, m, Ar, W, X, Y, Z and R.sup.1 have any of the meanings defined herein, and their pharmaceutically acceptable salts, and pharmaceutical compositions containing them. The novel compounds possess endothelin receptor antagonist activity and are useful, for example, in the treatment of diseases or medical conditions in which elevated or abnormal levels of endothelin play a significant causative role. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.