Patent · US Expired

Method for the preparation of citalopram

US6258842A · kind A · utility

29Cited by

2References

18Claims

0Family size

Assignee

H. LUNDBECK A/S · DK

Inventors

Hans Petersen
Peter Bregnedal · Lillerød, DK
Klaus Bogeso · Avenue Madeleine, DK

Key dates

Filing date	Apr 28, 2000
Grant date	Jul 10, 2001
Priority date	—
Expiry date	Apr 28, 2020

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D307/88
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A method for the preparation of citalopram is described comprising reaction of a compound of Formula (IV) wherein R.sup.1 is H or C.sub.1-6 alkylcarbonyl successively with a Grignard reagent of 4-halogen-fluorophenyl and a Grignard reagent of 3-halogen-N,N-dimethylpropylamine, effecting ring closure of the resulting compound of Formula (IV) and converting the resulting 1,3-dihydroisobenzofuran compound to the corresponding 5-cyano derivative, i.e. citalopram. ##STR1##

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.