RNA hydrolysis
US6258941A · kind A · utility
0Cited by
7References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 16, 1992 |
| Grant date | Jul 10, 2001 |
| Priority date | — |
| Expiry date | Sep 16, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H23/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The selected sequence-directed hydrolysis of RNA under physiologically relevant conditions is described using conjugates comprising metal complexes covalently linked to oligodeoxynucleotides as hydrolysis agents. The oligodeoxynucleotide portions of the agents are selected to provide molecular recognition via the Watson Crick base pairing to the target RNA sequence to be hydrolyzed. A method is described for determining the RNA hydrolysis effectiveness of metals and ligands used to form the metal complexes useful in this invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.