Live attenuated virus vaccines for western equine encephalitis virus, eastern equine encephalitis virus, and venezuelan equine encephalitis virus IE and IIIA variants

US6261570A · kind A · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Michael Parker · Frederick, US
• Jonathan F. Smith · Cary, US
• Bruce Crise · Frederick, US
• Mark Steven Oberste · Lilburn, US
• Shannon M. Schmura · Hagerstown, US

Key dates

• Filing date: Dec 16, 1997
• Grant date: Jul 17, 2001
• Expiry date: Dec 16, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/36122
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

cDNAs coding for an infectious Western Equine Encephalitis virus (WEE) and infectious Venezuelan Equine Encephalitis virus variant IE (VEE IE) are disclosed in addition to cDNA coding for the structural proteins of Venezuelan Equine Encephalitis virus variant IIIA (VEE IIIA). Novel attenuating mutations of WEE and VEE IE and their uses are described. Also disclosed are attenuated chimearic alphaviruses and their uses.