Expression cassettes encoding soluble, non-cleavable, chimeric HIV-1 GP160 variants, their methods of construction, and methods for the production of GP160 variants
US6261799A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 31, 1992 |
| Grant date | Jul 17, 2001 |
| Priority date | — |
| Expiry date | Dec 31, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16122
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention is directed toward soluble, non-cleavable, chimeric human immunodeficiency virus type 1 (HIV-1) gp160 variants, expression vectors encoding said variants, and methods of producing said variants. These HIV-1 gp160 variants comprise the following regions: I) a first region derived from the gp160 of a first strain of HIV-1; ii) a second region derived from the gp160 of a second strain of HIV-1 wherein said second region fails to contain functional major and minor proteolytic cleavage sites (amino acids 483-486 and 475-479, respectively) and functional major and minor hydrophobic domains (amino acids 487-516 and 659-680, respectively); and iii) an optional third region, derived from the gp160 of said second strain, located at the amino terminus of the recombinant envelope.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.