Two step enzymatic acylation
US6261813A · kind A · utility
4Cited by
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8Claims
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Key dates
| Filing date | Nov 23, 1998 |
| Grant date | Jul 17, 2001 |
| Priority date | — |
| Expiry date | Nov 23, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG11C11/401
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for derivatizing a compound having a hydroxyl group by back to back acylation is provided. The compound is acylated with a bifunctional acyl donor in the presence of a hydrolase to form an activated acyl ester or carbonate. Preferably the bifunctional acylating donor is a di(vinyl) ester or carbonate. The activated acyl ester or carbonate is then used to acylate a nucleophile in the presence of a lipase. The method of the invention provides regioselective enzymatic acylation of the base compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.