4-Oxo-3,5-dihydro-4H-pyridazino[4,5-b]-indole-1-acetamide derivatives, their preparation and their application in therapy

US6262045A · kind A · utility

Assignee

• Sanofi-Synthelabo · FR

Inventors

• Yannick Evanno · Rambouillet, FR
• Laurent Dubois · Le Plessis-Robinson, FR
• Mireille Sevrin · Paris, FR
• Frank Marguet · Verrières-le-Buisson, FR
• Jacques Froissant · Châteaudun, FR
• Regine Bartsch · Fontenay-aux-Roses, FR
• Catherine Gille · Antony, FR

Key dates

• Filing date: Apr 13, 2000
• Grant date: Jul 17, 2001
• Expiry date: Apr 13, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of general formula (I) ##STR1## in which X represents a hydrogen or halogen atom or a methyl, methoxy or phenylmethoxy group, Y represents a hydrogen atom, 1 or 2 halogen atoms or a hydroxyl, methoxy, nitro or methyl group, R.sub.1 represents a hydrogen atom or a (C.sub.1 -C.sub.4)alkyl group, R.sub.2 and R.sub.3 each represent a hydrogen atom, a (C.sub.1 -C.sub.4)alkyl group or a phenylmethyl group or else R.sub.2 and R.sub.3 form, with the nitrogen atom which carries them, an azetidinyl, pyrrolidinyl, 3-ethoxypyrrolidinyl, piperidinyl, morpholinyl, 4-methylpiperazinyl or 1,3-thiazolidinyl group. Application in therapeutics.