Lactam derivatives as antiarrhythmic agents

US6262068A · kind A · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Karnail Atwal · Newtown, US
• Saleem Ahmad · Wall, US
• Francis N. Ferrara · Bound Brook, US

Key dates

• Filing date: Jan 14, 1999
• Grant date: Jul 17, 2001
• Expiry date: Jan 14, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Lactam derivatives of the formula ##STR1## where PA1 X is --C(.dbd.O)NR.sup.3' --, --NR.sup.3' C(.dbd.O)--, --C(.dbd.NCN)NR.sup.3' --, --NR.sup.3' C(.dbd.NCN)--, --CH.sub.2 NR.sup.3' --, --CH(alkyl)NR.sup.3' --, --CH(COOalkyl)NR.sup.3' --, --CH(CH.sub.2 OH)NR.sup.3' --, --C(CH.sub.2 Oalkyl)--; PA1 R.sup.1 is halo, alkyl, cycloalkyl, alkyl(cycloalkyl), aryl, (aryl)alkyl, (aryl)alkenyl, (aryl)alkynyl, O-alkyl, O-alkenyl, O-aryl, O-alky(aryl), O-alkyl(heterocyclo), COO-alkyl, C)-alkyl, CO-amino, CO-substituted amino, alkyl-CO-amino, alkyl-CO-substituted amino, NHCO-alkyl, NHCO-aryl, NHCO-alkyl(aryl), NHCO-alkyl(heterocyclo), N(alkyl)CO-alkyl, N(alkyl)CO-aryl, N(alkyl)CO-heterocyclo, N(alkyl)CO-alkyl(aryl), N(alkyl)CO-alkyl(heterocyclo); PA1 R.sup.2 is hydrogen, alkyl, halo, aryl, (aryl)alkyl, O-alkyl, amino, substituted amino; PA1 R.sup.3 and R.sup.3' are the same or different and are independently selected from hydrogen, alkyl or alkyl(aryl); PA1 R.sup.4 which can be bonded to a ring carbon or nitrogen, is selected from hydrogen, alkyl, alkenyl, alky(aryl), alkyl(heterocyclo), cycloalkyl, alkyl(cycloalkyl), alkyl-(amino), alkyl-(substituted amino), alkyl-NHCO(alkyl), alkyl-NHCO(aryl)…