1-amino-7-isoquinoline derivatives as serine protease inhibitors
US6262069A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 25, 2000 |
| Grant date | Jul 17, 2001 |
| Priority date | — |
| Expiry date | Feb 25, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
##STR1## The invention relates to serine protease inhibitor compounds of fornula (I) where R.sub.1 is hydrogen, halo, cyano, nitro or hydroxyl, amino, alkoxy, alkyl amminoalkyl, hydroxyalkyl, thiol, alkylthio, aminosulphonyl alkoxyalkyl, alkoxycarbonyl, acyloxymethoxycabonyl or alkylamino optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl, cycloalkyl, amino, halo, cyano, nitro, thiol, alkylthio, alkylsulphonyl, alkylsulphenyl, alkylsulphonamido, alkylaminosulphonyl, haloalkoxy and haloalkyl; R.sub.2 is hydrogen, halo, methyl amino, hydroxy, or oxo; and R is X--X--Y(R.sub.7)--L--Lp(D)n; wheren each X independently is a C, N, O or S atom or a CO, CR.sub.1, C(R.sub.1).sub.2 or NR.sub.1 group, at least one X being C, CO, CR.sub.1 or a C(R.sub.1).sub.2 group; Y (the .alpha.-atom) is a nitrogen atom or a CR.sub.1 group or Y and L taken together form a cyclic group; R.sub.7 is a lipophilic group selected from alkyl, alkenyl, mono- or bi-cycloalkyl, aryl, heteroaryl, mono- or bicycloalkylalkyl, mono- or bicycloalkylakenyl, aralkyl, heteroaryl-alkyl, arylalkenyl, heteroarylalkenyl all optionally substituted by a group R.sub.1 ; L is an organic linker group containing 1 to 5 ba…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.