Aminopyridine-containing thiourea inhibitors of herpes viruses
US6262090A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 22, 1999 |
| Grant date | Jul 17, 2001 |
| Priority date | — |
| Expiry date | Nov 22, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula ##STR1## PA1 wherein PA1 A is heteroaryl; PA1 R.sub.9 -R.sub.12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R.sub.9 and R.sub.10 or R.sub.11 and R.sub.12 may be taken together to form aryl of 5 to 7 carbon atoms; PA1 W is O, NR.sub.6, or is absent; PA1 G is aryl or heteroaryl; and PA1 X is a bond X is a bond, --NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; and PA1 J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and PA1 n is an integer from 1 to 6; or a pharmaceutical acceptable salt thereof, useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.