Use of tricyclic derivatives of 1,4-dihydro-1,4-dioxo-1H-naphthalene, novel compounds obtained and their application in theraphy

US6262095A · kind A · utility

Assignee

• Laboratoire Innothera societe Anonyme · FR

Inventors

• Odile Boutherin-Falson · Palaiseau, FR
• Stephanie Desquand-Billiald · Paris, FR
• Anita Favrou · Cachan, FR
• Michel Finet · Fresnes, FR
• Olivier Tembo · Saint-Quentin, FR
• Jean-Luc Torregrosa · Saint-Denis, FR
• Sylvie Yannic-Arnoult · Épinay-sur-Orge, FR
• Florence Domagala-Le Marquer · Antony, FR

Key dates

• Filing date: Oct 14, 1998
• Grant date: Jul 17, 2001
• Expiry date: Oct 14, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns the therapeutic use of tricyclic salts and their pharmaceutically acceptable salts having the general formula: ##STR1## in which: PA1 A is either a sulfur atom, an oxygen atom, or an R.sub.3 N radical where R.sub.3 is a hydrogen atom, a C.sub.1 -C.sub.5 alkyl radical, or a substituted or unsubstituted aromatic ring, or a substituted or unsubstituted heteroaromatic ring. PA1 R.sub.1 is either a C.sub.1 -C.sub.5 alkyl radical, PA1 or an R.sub.4 NH radical where R.sub.4 is a hydrogen atom, a C.sub.1 -C.sub.5 alkyl radical, or a substituted or unsubstituted aromatic ring, or a substituted or unsubstituted heteroaromatic ring, PA1 or an aromatic ring that may or may not be substituted by one or more acceptor or donor groups, or a heteroaromatic ring having one or more heteroatoms, which may or may not be substituted by acceptor or donor groups. PA1 R.sub.2 is a hydrogen atom, halogen atom, a C.sub.1 -C.sub.5 alkyl radical, an oxygen atom that may or may not be substituted by a C.sub.1 -C.sub.5 alkyl radical, or an NR.sub.5 R.sub.5, radical where R.sub.5 and R.sub.5, are, independently of each other, a hydrogen atom, an oxygen atom or monovalent C.sub.1 -C.sub.5 or…