Polymeric matrices and their uses in pharmaceutical compositions

US6262127A · kind A · utility

Assignee

• Novartis AG · CH

Inventors

• Murat Acemoglu · Basel, CH
• Siegfried Bantle · Arlesheim, CH
• David Bodmer · Klingnau, CH
• Salvatore Cammisuli · Reinach, CH
• Peter C. Hiestand
• Fritz Nimmerfall · Bottmingen, CH
• Georg Stoll · Munich, DE

Key dates

• Filing date: Jul 20, 1999
• Grant date: Jul 17, 2001
• Expiry date: Jul 20, 2019

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides pharmaceutical compositions comprising polymeric matrices, especially those comprising IL-6 as an active ingredient. Specific novel poly(ethylene carbomate) polymers are also provided for more general use as matrix materials in sustained release compositions containing pharmacologically active compounds, as are methods of using of IL-6 for treatment of conditions mediated by IL-1 and/or TNF.alpha., e.g., certain autoimmune and inflammatory conditions, as well as septic shock.