Tumor suppressor designated TS10Q23.3

US6262242A · kind A · utility

Assignees

• The Board of Regents of the University of Texas System · US
• Myriad Genetics, Inc. · US

Inventors

• Peter Steck · Bellaire, US
• Mark A. Pershouse · Houston, US
• Samar A. Jasser · Houston, US
• W. K. Alfred Yung · Houston, US
• Sean V. Tavtigian · Val-de-Reuil, FR

Key dates

• Filing date: Jan 30, 1997
• Grant date: Jul 17, 2001
• Expiry date: Jan 30, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2799/021
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.