8-fluoropurine compounds

US6262254A · kind A · utility

Assignee

• THE REGENTS OF THE UNIV. OF CALIFORNIA · US

Inventors

• Jorge R. Barrio · Craydon Court, US
• Nagichettiar Satyamurthy · Los Angeles, US
• Mohammad Namavari · Los Angeles, US
• Michael E. Phelps · Calabasas, US

Key dates

• Filing date: Nov 25, 1998
• Grant date: Jul 17, 2001
• Expiry date: Nov 25, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F.sub.2 in He or other inert gas.