Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay
US6262265A · kind A · utility
6Cited by
27References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 18, 1999 |
| Grant date | Jul 17, 2001 |
| Priority date | — |
| Expiry date | Jun 18, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/9486
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Novel chemical analogs are disclosed for the essential heroin metabolite 6-O-acetyl morphine (6MAM). The analogs optionally can be made to contain protein reactive groups, and can be used to form protein conjugates, fluorescently labeled compounds, and solid-phase adsorbants. The proteins conjugates can be used in turn to raise antibodies reactive with 6MAM and having a low cross-reactivity with the closely related opiates, morphine and codeine. The antibodies can be used in combination with labeled analogs in exquisitely sensitive immunoassays suitable for testing for heroin abuse.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.