Process for preparing N-[1-(S)-ethyoxycarbonyl-3-phenylpropyl]-L-ananine N-carboxyanhydride
US6262274A · kind A · utility
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12Claims
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Key dates
| Filing date | Oct 13, 2000 |
| Grant date | Jul 17, 2001 |
| Priority date | — |
| Expiry date | Oct 13, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride of the following formula (I), ##STR1## is to react N-[1 -(S)-ethyoxy carbonyl-3-phenylpropyl]-L-alanine with XCOOR, wherein X is halogen atom, R is C.sub.1 -C.sub.6 alkyl, to obtain a N-alkoxycarbonyl compound, then reacting with an acyl group activation reagent, finally contact with water. The compound of formula (I) is a key intermediate of ACE inhibitors.
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