.omega.-Cycloalkly-prostaglandin e2 derivatives
US6262293A · kind A · utility
27Cited by
2References
16Claims
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Assignee
Inventors
Key dates
| Filing date | Jun 23, 2000 |
| Grant date | Jul 17, 2001 |
| Priority date | — |
| Expiry date | Jun 23, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C405/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
.omega.-Cycloalkyl-prostaglandin E.sub.2 derivatives of formula (I) ##STR1## (wherein all symbols are as defined in the description); and non-toxic salts thereof, prodrugs thereof and cyclodextrin clathrates thereof. Compounds of formula (I) strongly bind on the EP2 subtype receptor. Therefore, they are useful for prevention and/or treatment of immunological diseases (autoimmune diseases, organ transplantation etc.), asthma, abnornmal bone formation, neuronal cell death, liver damage, abortion, premature birth or retina neuropathy of glaucoma etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.